AII Knowledge Center
Research • Education • Perspectives • Innovation
AII's library of educational resources exploring medication preparation, handling, and delivery.
Dedicated to advancing the science and practice of medication preparation, handling, and delivery.
🔬 Evidence Review
Summaries and analyses of published research relevant to medication preparation, handling, and delivery.
🎧 Each review includes an audio version
AII’s collection of evidence-based publications, scientific reviews, and technical analyses exploring medication preparation, handling, and delivery.
📄 White Papers
January 2025
PDF • 22 pages
March 2025
PDF • 11 pages
February 2026
PDF • 11 pages
May 2025
PDF • 11 pages
January 2025
PDF • 16 pages
📘 Educational Articles
Explore practical explanations of healthcare concepts, best practices, and emerging topics designed to educate and inform.
🎧 Each Article includes an audio version
💡 Perspectives
Thoughtful commentary and informed viewpoints from AII, clinicians, advisors, and industry leaders.
🎧 Each Perspective includes an audio version
Innovation does not always begin inside a laboratory or healthcare facility. Sometimes, a familiar challenge becomes clearer when viewed through the lens of another industry, a natural system, or an everyday observation.
Innovation Reflections explores those connections—and considers what they might teach us about medication stewardship, healthcare efficiency, patient care, and the systems surrounding them.
Innovation Reflections
🎧 Each Reflection includes an audio version
🎥 Videos
Educational videos, demonstrations, webinars, presentations, and interviews.
Expert Perspectives
Hear from clinicians, pharmacists, researchers, veterinarians, and industry leaders as they share insights on medication stewardship, biologics, innovation, and the future of medication preparation.
Biopharmaceutical Perspective: Why Medication Stewardship Matters
Michael Handley
Chief Executive Officer, Tivic Biopharma
Michael Handley discusses medication stewardship from the perspective of the biopharmaceutical industry, explaining how reducing waste can improve patient care, lower healthcare costs, and support broader adoption of innovative biologic therapies.
Optimizing Care Through Medication Stewardship
Dr. Jaime Pickett, DVM, MBA
Chief Veterinary Officer, Alexander International Innovations
Dr. Jaime Pickett discusses how improving medication preparation extends beyond reducing waste. She explains how technologies that improve efficiency, medication utilization, and sustainability can help clinicians deliver better patient care while making more responsible use of healthcare resources.
From the Infusion Chair to Better Patient Care
Maeve E. O'Connor MD, FACAAI, FAAAAI, FACP
Chief Medical Officer, Alexander International Innovations
Dr. Maeve O'Connor shares her firsthand experience preparing infusions and explains how even small amounts of medication waste can have a significant clinical and financial impact. She discusses why improving medication recovery benefits patients, providers, healthcare systems, and payers while enhancing the safety and accuracy of infusion therapy.
Protecting Medication Integrity from Vial to Patient
Elena Kline PharmD, BCGP, BCACP
Clinical Pharmacist, Alexander International Innovations
Elena Kline explains how reducing air introduction during medication preparation can help minimize foaming, protein aggregation, medication loss, and hazardous drug exposure. She also discusses the importance of accurate medication recovery and inventory control when working with high-value biologics and controlled substances.
A Simple Solution to a Long-Standing Problem
Dr. Clayton Hellner, DVM
Veterinarian, CMO NewDay Veterinary Care
Dr. Clayton Hellner explains why I2F stood out to him as a simple yet impactful innovation. He discusses how reducing medication spray, foaming, pressure buildup, and waste can improve medication accuracy, staff safety, and controlled substance accountability.
Simplicity That Solves a Real Problem
Temple Grandin, Ph.D.
Professor of Animal Science, Colorado State University
Temple Grandin shares her perspective on I2F's simple yet practical design, highlighting its ability to reduce medication waste and prevent medication spray during vial preparation.
Educational Demonstrations
See medication preparation concepts in action through product demonstrations, comparisons, and instructional videos.
What is I2F?
I2F (Improved Fluid Flow) is a patented device designed to improve the preparation of injectable and infusion medications by reducing vial overpressure, minimizing foaming, and improving medication recovery.
Controlled Substances: Every Drop Must Be Accounted For
Controlled substances require precise documentation, but medication spray caused by vial overpressure can result in unrecorded medication loss. This demonstration explains how I2F helps eliminate overpressure during withdrawal, improving medication recovery and supporting accurate controlled substance accountability.
How I2F Reduces Medication Waste and Pays for Itself
Medication waste from vial overpressure often goes unnoticed, but even small losses can add up to significant costs over time. This demonstration shows how I2F eliminates medication spray during withdrawal, improves medication recovery, and helps facilities reduce waste while increasing operational efficiency.
🧪 Research & Innovation
Follow our latest research initiatives, scientific collaborations, product development, and innovation.