Information for Healthcare Professionals

Introducing I2F: A Smarter Way to Infuse

At Alexander International Innovations, we are proud to introduce I2F, a patented, nurse-invented medical device designed to improve the safety, efficiency, and value of intravenous therapy—especially for patients receiving plasma-derived medications like IVIG.

The idea behind I2F was born at the bedside. While caring for immunosuppressed patients, a nurse with nearly 30 years of experience noticed significant medication waste during the pooling of IVIG into infusion bags. The foaming that occurred in the glass vials led to discarded medication—despite observations showing that the foam eventually settled back into usable liquid. After analyzing hundreds of pooled vials over time, it was clear: up to 5% of each dose was being lost unnecessarily.

This matters. Studies on IVIG pharmacokinetics show that serum IgG levels increase by approximately 2.5 g/L for every 0.1 g/kg of IGIV administered. Even a small reduction in wasted medication could help patients maintain higher IgG levels, especially during the critical “trough” period when they’re most vulnerable to infection. Reducing that waste could mean fewer infections, fewer hospitalizations, and better outcomes.

I2F eliminates foaming during pooling or infusion, ensuring more of each dose reaches the patient. The device is simple to use, fits into your existing setup beside the IV spike set, and has been shown to reduce nurse and pharmacy prep time.