“I have not failed. I’ve just found 10,000 ways that won’t work.“

Thomas Edison

Information for Patients

IF YOU RECEIVE IVIG OR OTHER PLASMA-DERIVED MEDICATIONS, THERE IS GOOD CHANCE YOU ARE NOT RECEIVING YOUR FULL DOSE YOUR DOCTOR PRESCRIBED.

Foaming medication
wasted medication

WASTED MEDICATION

^^^

WASTED MEDICATION ^^^

Waste is a very big problem. Until now, there hasn’t been a way to eliminate the waste created by the current method.

How much medication is wasted during an infusion of IVIG?

There is an average 2-5% waste. This can be up to 2 Grams of IVIG.

What causes the waste?

IVIG (and other plasma-derived medications) are made of human plasma. It is susceptible to foaming when agitated. The current method of administration uses a vented IV tubing spike. This vented spike allows bubbles to travel through the medication which causes the medication to foam. (see photos above and video below)

Is 2-5% waste a big deal?

Health benefits - 2-5% can be the difference in you getting sick before your next [IVIG] infusion.

Financial benefits - The average IVIG infusion costs $10,000. 2-5% waste translates to wasting up to $500 worth of medication each time you have an infusion.

What can be done to eliminate the waste?

Your healthcare provider can use the new I2F device.

What is the I2F?

The I2F is a device that allows you to receive your full dose of medication.

How is the I2F used and how does it work?

The I2F is inserted next to the spike that goes into each bottle you are administered. It works by allowing air to enter the bottle and extends past the fluid so the air does not travel through the medication. It eliminates waste caused by the current method of administration. See video below.

Which medications should the I2F be used with?

The I2F can be used with any plasma-derived medication like IVIG and Albumin. We are continuing to test our device with other medications that foam that could benefit from the use of the I2F. See list of medications below.

How can I talk to my provider about this?

Click here to download an information sheet for your provider.

Demonstration of the I2F


List of medications that the I2F can be used with.

  • Albumin

  • Alpha 1-Proteinase Inhibitor

  • Anti-Inhibitor Coagulation Complex (AICC)

  • Anti-Thrombin III Concentrate

  • Asceniv

  • Bivigam

  • Carimune

  • CytoGam

  • Cytomegalovirus (CMV)

  • Factor IX Concentrate

  • Factor VIII Concentrate

  • Flebogamma

  • Gammagard

  • Gammaked

  • Gammaplex

  • Gamunex C

  • Immune Globulins, including Rh Immune Globulin

  • Octagam

  • Panzyga

  • Privigen

Diagnosis that may require use of plasma-derived medications

  • Autoimmune encephalitis

  • B-cell chronic lymphocytic leukemia (B-cell CLL)

  • Birdshot retinochoroidopathy

  • Bone marrow transplantation

  • Chronic inflammatory demyelinating polyneuropathy (CIDP)

  • Common Variable Immunodeficiency (CVID)

  • Guillain–Barré syndrome (GBS)

  • Henoch-Schönlein purpura

  • HIV infection

  • Idiopathic (immune) thrombocytopenic purpura (ITP)

  • Immune thrombocytopenia (IT)

  • Inflammatory myopathies

  • Kawasaki disease (KD)

  • Lupus

  • Myasthenia Gravis

  • Myositis

  • Multifocal motor neuropathy (MMN)

  • Multiple myeloma (MM)

  • Neonatal sepsis

  • Neuromyelitis optica

  • Primary immunodeficiencies

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Toxic shock syndrome